September 2016 - Carmel Diagnostics ltd. was chosen by the EC (European Commission) and won a grant from SME Instrument, part of Horizon2020 program. Carmel prepared and submitted an extensive feasibility study for its project FERTISSIMO, dealing with development of the Embryo Selection application and preparation for market launch.

Carmel will apply to Phase-2 of SME Instrument and hopes to get the funding to perform the project. Carmel is proud to be selected. This is an endorsement for the technology, the project and the application.

Carmel’s project has also received a “Seal of Excellence” from the EC pursuant submission of an application and project plan.

June 30, 2014 - A joint project of Carmel Diagnostics and IVI Valencia has been selected as the recipient of the prestigious Merck Serono Grant for Fertility Innovation (GFI) award. The award was announced at the 30th Annual Meeting of the European Society of Human Reproduction and Embryology (ESHRE) that took place in Munich, Germany.

GFI program is a global award program, started in 2009, dedicated to transforming innovative fertility research projects into concrete health solutions to improve the outcomes of assisted reproductive technologies. This year, over 150 scientific grant applications from 25 countries were submitted for blind review from the GFI scientific committee.

The Principal Investigator will be Dr. Marcos Meseguer, Scientific Supervisor in the IVF unit of IVI Valencia - a world class researcher who led the clinical validation of Embryoscope (a product of Unisense Fertilitech). He is also currently Statistic Advisor in IVI Valencia - the biggest infertility clinic in Spain and one of the most important in Europe, and associate professor of the Master in Biotechnology from Valencia University.

"We are honored to be part of this prestigious award and very pleased to collaborate with Dr. Marcos Meseguer at the IVI Clinics in Spain in this important study," said Tzali Cnaani CEO of Carmel Diagnostics.

The Project: Embryo viability measurement combining Oxidative stress and time-lapse

The planned project will further validate the quality of oxidative stress as a biomarker assisting embryo selection. We plan to improve the correlation formula between the measured parameters of TCL Analyzer and the embryo viability (expressed as a score to compare each embryo with the same cohort of embryos of the same patient).

The main goal of the project is building a combined assessment algorithm that will include the information from the time-lapse system (kinetic information of cleavage), information from TCL Analyzer (biochemical measurement that examines the oxidative profile, (also connected to signal transduction which is based on free radicals activity), the metabolism of the embryo with the culture media where it grows. The TCL Analyzer has shown to be an effective tool to predict the viability of an embryo. A study that tested over 270 embryos showed that TCL can provide good prediction of embryos to be transferred and assist in selecting the most viable embryos by testing the spent culture media. The system is based on measuring oxidative stress and oxidizability that are used as biomarkers indicating the chances for pregnancy.

Several studies by IVI have demonstrated the utility of time-lapse morphokinetics to assess embryo quality and improve embryo selection for transfer.

The project may use morphological data and examines whether a united score of these two (three sources) will provide a better prediction and will increase the success rate of the IVF process. The project will include Retrospective studies of 200 cycles, (we plan to conduct both Single embryo transfer study and multi embryo transfer study) One "branch of the study will compare the measured parameter and the algorithm with the rate of reaching blastocyst when the embryo will further be incubated.

We also plan a prospective study of 200 cycles (including control group), and additional study that will test the combined score given by TCL and the time lapse system.
Another goal of the project is examining optimal time for transfer and the connection between the time and the effectivity of the various algorithms. We'll also examine whether there is a connection between the type of the culture media and the results.